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Best Supplements for Focus

Evidence-based ranking of supplements options for focus. Updated February 2026.

#1 PickBased on 48+ studies

Creatine

Score: 9.1/10. Sustained mental performance under stress

5g daily 2-4 weeks $

Complete Rankings

#1
CreatineTop Pick
9.1

Sustained mental performance under stress

PROS

  • Boosts brain ATP
  • Well-studied
  • Cheap and safe

CONS

  • • Subtle cognitive effects
  • • Takes weeks to saturate
Dose: 5g dailyTiming: Consistent daily timingOnset: 2-4 weeksCost: $
Full analysis →
#2
8.9

Alert focus without jitters

PROS

  • Synergistic pairing
  • Smooth focus
  • Fast acting

CONS

  • • Still contains caffeine
  • • Tolerance possible
Dose: 100-200mg theanine + 50-100mg caffeineTiming: As neededOnset: 30 minutesCost: $
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#3
Lion's ManeBest for Long-term
8.4

Long-term cognitive support, memory

PROS

  • NGF support
  • Neuroprotective
  • No stimulation

CONS

  • • Takes months
  • • Quality varies greatly
Dose: 500-1000mg extractTiming: Any timeOnset: 4-8 weeksCost: $$
Full analysis →
#4
Omega-3 (DHA)Essential Foundation
8.2

Brain health foundation, especially if low fish intake

PROS

  • Brain structure
  • Well-studied
  • Multiple benefits

CONS

  • • Subtle effects
  • • Fish burps possible
Dose: 1-2g EPA+DHATiming: With mealsOnset: 4-8 weeksCost: $$
Full analysis →

Quick Comparison

SupplementScoreDoseOnsetCost
Creatine9.15g daily2-4 weeks$
L-Theanine + Caffeine8.9100-200mg theanine + 50-100mg caffeine30 minutes$
Lion's Mane8.4500-1000mg extract4-8 weeks$$
Omega-3 (DHA)8.21-2g EPA+DHA4-8 weeks$$

Common Questions

Based on clinical evidence, Creatine ranks as the top choice for focus. It scores 9.1/10 due to Boosts brain ATP and Well-studied. Sustained mental performance under stress.

Compare Top 2

Creatine vs L-Theanine + Caffeine

Focus Stack Guide

Complete protocol with timing

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How We Rank

Our rankings are based on: clinical evidence quality (40%), effect size (30%), safety profile (20%), and value (10%). We analyze meta-analyses and RCTs from PubMed, Cochrane, and peer-reviewed journals.

Disclaimer: This is educational content, not medical advice. Consult a healthcare provider before starting any supplement regimen.