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Best Supplements for Anxiety

Evidence-based ranking of supplements options for anxiety. Updated February 2026.

#1 PickBased on 48+ studies

Ashwagandha (KSM-66)

Score: 9/10. Chronic stress and general anxiety

300-600mg KSM-66 extract 2-4 weeks $$

Complete Rankings

#1
9

Chronic stress and general anxiety

PROS

  • Strong evidence
  • Reduces cortisol
  • Improves stress resilience

CONS

  • • Takes 4-8 weeks
  • • May affect thyroid
  • • Not for pregnancy
Dose: 300-600mg KSM-66 extractTiming: Morning or eveningOnset: 2-4 weeksCost: $$
Full analysis →
#2
L-TheanineBest for Acute Anxiety
8.7

Situational anxiety, public speaking, performance

PROS

  • Works quickly
  • No sedation
  • Safe to combine

CONS

  • • Effects are subtle
  • • May need higher doses
Dose: 200-400mgTiming: As needed or dailyOnset: 30-60 minutesCost: $
Full analysis →
#3
Magnesium GlycinateBest Foundation
8.5

Foundational support, especially if deficient

PROS

  • Addresses common deficiency
  • Calms nervous system
  • Helps sleep

CONS

  • • Takes time to build up
  • • Large pills
Dose: 300-400mgTiming: EveningOnset: 1-2 weeksCost: $$
Full analysis →
#4
Rhodiola RoseaBest for Burnout
8.2

Stress-related fatigue and burnout

PROS

  • Reduces fatigue
  • Improves focus
  • Adaptogenic

CONS

  • • May cause insomnia if taken late
  • • Quality varies
Dose: 200-400mg (3% rosavins)Timing: Morning on empty stomachOnset: 1-2 weeksCost: $$
Full analysis →

Quick Comparison

SupplementScoreDoseOnsetCost
Ashwagandha (KSM-66)9300-600mg KSM-66 extract2-4 weeks$$
L-Theanine8.7200-400mg30-60 minutes$
Magnesium Glycinate8.5300-400mg1-2 weeks$$
Rhodiola Rosea8.2200-400mg (3% rosavins)1-2 weeks$$

Common Questions

Based on clinical evidence, Ashwagandha (KSM-66) ranks as the top choice for anxiety. It scores 9/10 due to Strong evidence and Reduces cortisol. Chronic stress and general anxiety.

Compare Top 2

Ashwagandha (KSM-66) vs L-Theanine

Anxiety Stack Guide

Complete protocol with timing

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How We Rank

Our rankings are based on: clinical evidence quality (40%), effect size (30%), safety profile (20%), and value (10%). We analyze meta-analyses and RCTs from PubMed, Cochrane, and peer-reviewed journals.

Disclaimer: This is educational content, not medical advice. Consult a healthcare provider before starting any supplement regimen.