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Best Supplements for Energy

Evidence-based ranking of supplements options for energy. Updated February 2026.

#1 PickBased on 48+ studies

Creatine

Score: 9.4/10. Physical and mental energy, cognitive performance

5g daily 2-4 weeks $

Complete Rankings

#1
CreatineTop Pick
9.4

Physical and mental energy, cognitive performance

PROS

  • Decades of research
  • Brain + muscle energy
  • Very safe

CONS

  • • Water retention initially
  • • Takes time to saturate
Dose: 5g dailyTiming: Any time, consistency mattersOnset: 2-4 weeksCost: $
Full analysis →
#2
Rhodiola RoseaBest for Mental Energy
8.6

Mental fatigue, burnout, demanding work

PROS

  • Reduces fatigue
  • Improves mood
  • Works relatively fast

CONS

  • • Stimulating - avoid PM
  • • Extract quality varies
Dose: 200-400mgTiming: MorningOnset: 1 weekCost: $$
Full analysis →
#3
Iron (if deficient)Essential if Low
8.4

Women, vegetarians, those with tested deficiency

PROS

  • Dramatic improvement if deficient
  • Addresses root cause

CONS

  • • Only helps if deficient
  • • Can cause GI issues
Dose: Based on blood testTiming: Morning with vitamin COnset: 2-4 weeksCost: $
Full analysis →
#4
CoQ10Best for 40+
8.1

Adults over 40, statin users

PROS

  • Cellular energy
  • Heart health
  • Counters statin effects

CONS

  • • Expensive
  • • Takes time
Dose: 100-200mg ubiquinolTiming: With fatty mealOnset: 4-8 weeksCost: $$$
Full analysis →

Quick Comparison

SupplementScoreDoseOnsetCost
Creatine9.45g daily2-4 weeks$
Rhodiola Rosea8.6200-400mg1 week$$
Iron (if deficient)8.4Based on blood test2-4 weeks$
CoQ108.1100-200mg ubiquinol4-8 weeks$$$

Common Questions

Based on clinical evidence, Creatine ranks as the top choice for energy. It scores 9.4/10 due to Decades of research and Brain + muscle energy. Physical and mental energy, cognitive performance.

Compare Top 2

Creatine vs Rhodiola Rosea

Energy Stack Guide

Complete protocol with timing

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How We Rank

Our rankings are based on: clinical evidence quality (40%), effect size (30%), safety profile (20%), and value (10%). We analyze meta-analyses and RCTs from PubMed, Cochrane, and peer-reviewed journals.

Disclaimer: This is educational content, not medical advice. Consult a healthcare provider before starting any supplement regimen.