EVIDENCE-BASED
47,000+ trials analyzed
59,000+ interactions
Not FDA evaluated

What Actually Works for Immunity?

After 2020, everyone wants to "boost their immune system." The truth: you can't really "boost" it, but you can stop weakening it. Here's what actually helps.

TL;DR

Best evidence: Vitamin D (if deficient), Zinc (for cold duration), Vitamin C (modest prevention). Moderate evidence: Elderberry (may shorten colds). Doesn't work: Immune "boosters," mega-doses of anything, most herbal blends.

A

Strong Evidence (Fix Deficiencies)

Vitamin D
1000-4000 IU daily30 studies

Reduces respiratory infection risk if deficient

8-12 weeks

Note: Only helps if you're actually low. Get tested.

Zinc (for colds)
75mg+ daily lozenges (during cold)15 studies

Shortens cold duration by 1-3 days if taken immediately

Must start within 24 hours

Note: Only works if started at first symptoms

Vitamin C
200-1000mg daily25 studies

May reduce cold duration by 8% in adults

Ongoing

Note: Effect is modest. Food sources often sufficient.

B

Moderate Evidence

Elderberry
600-900mg daily during illness8 studies

May shorten cold/flu duration

2-4 days

Note: Some evidence, but not overwhelming.

Probiotics (specific strains)
Strain-specific20 studies

Some strains may reduce cold frequency/duration

4-8 weeks

Note: L. rhamnosus GG, B. lactis have best evidence.

F

Doesn't Work / Overhyped

Echinacea
Various5 studies

Meta-analyses show inconsistent, minimal benefit

N/A

Note: One of the most studied herbs. Results disappointing.

Immune "Boosters"
Various

You can't actually "boost" your immune system

N/A

Note: Marketing term. An overactive immune system is bad (autoimmunity).

No better than moderate doses, may cause GI issues

N/A

Note: More is not better. Your body can only use so much.

Real Talk

"Boosting" your immune system is a marketing term, not a medical concept. Your immune system needs to be balanced, not boosted. What actually helps is not being deficient in key nutrients (D, zinc, C) and not sabotaging your immunity with poor sleep, chronic stress, and bad diet.

What Else Actually Helps

  • Sleep. 7-9 hours. Sleep deprivation tanks immunity
  • Exercise. moderate exercise improves immune function
  • Stress management. chronic stress suppresses immunity
  • Wash your hands. most effective intervention
  • Avoid smoking/excessive alcohol. both impair immunity

The Bottom Line

Fix deficiencies (vitamin D, zinc). Don't waste money on "immune boosters." Sleep, exercise, and hand hygiene matter more than any supplement.

Related Guides

About this information: Our recommendations draw from peer-reviewed clinical trials, systematic reviews, and the same medical databases your doctor uses. These statements have not been evaluated by the FDA. Supplements are not intended to diagnose, treat, cure, or prevent any disease.

Moderate Evidence

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