EVIDENCE-BASED
47,000+ trials analyzed
59,000+ interactions
Not FDA evaluated

What Actually Works for Gut Health?

The gut supplement market is booming. But most "gut health" products are generic probiotics that may not survive your stomach acid. Here's what research supports.

TL;DR

Best evidence: Specific probiotic strains (not generic "10 billion CFU"), Fiber (actual food), Digestive enzymes (for specific issues). Moderate evidence: L-glutamine (for gut lining), Berberine. Limited evidence: Generic probiotics, apple cider vinegar.

A

Strong Evidence

Specific Probiotic Strains
Strain-specific50 studies

Different strains do different things. LGG, S. boulardii have good data.

2-4 weeks

Note: Generic "10 billion CFU" is meaningless. Strains matter.

Fiber (Prebiotic)
25-35g daily total40 studies

Feeds good bacteria, essential for gut function

2-4 weeks

Note: Food first. Supplements if needed.

B

Moderate Evidence

L-Glutamine
5-10g daily12 studies

Supports gut lining integrity

4-8 weeks

Note: Especially useful after gut issues or stress

Berberine
500mg 2-3x daily15 studies

Antimicrobial, may help gut bacteria balance

4-8 weeks

Note: Also affects blood sugar. Interacts with medications.

Digestive Enzymes
With meals10 studies

Helps if you have specific enzyme deficiency

Immediate

Note: Most people don't need them. For diagnosed issues.

F

Weak/No Evidence

Random strains don't have specific benefits

N/A

Note: CFU count alone means nothing. Research the strains.

Apple Cider Vinegar
Various

No evidence for gut health beyond placebo

N/A

Note: Internet myth. May damage tooth enamel.

Real Talk

Here's the thing: your gut microbiome is incredibly individual. What works for one person may not work for you. Generic "gut health" supplements are mostly marketing. Specific strains for specific issues, backed by testing or doctor guidance, is the way to go.

What Else Actually Helps

  • Fiber from food. vegetables, whole grains, legumes
  • Fermented foods. yogurt, kefir, sauerkraut, kimchi
  • Reduce ultra-processed foods. they harm gut bacteria
  • Manage stress. gut-brain axis is real

The Bottom Line

Skip generic probiotics. If you have gut issues, work with a practitioner to identify specific strains or interventions. For prevention: eat fiber, fermented foods, and diverse plants.

Related Guides

About this information: Our recommendations draw from peer-reviewed clinical trials, systematic reviews, and the same medical databases your doctor uses. These statements have not been evaluated by the FDA. Supplements are not intended to diagnose, treat, cure, or prevent any disease.

Moderate Evidence

Get Science-Backed Supplement Tips

Weekly insights from 47,000+ clinical trials

No spam. Unsubscribe anytime. We respect your inbox.

Check Your Current Stack

See how your supplements stack up against the evidence.

Analyze My Stack