Best Supplements for Liver Health

Supporting your body's main detoxification organ

The liver processes everything you consume and produces essential proteins. Supporting it makes sense, especially if you drink alcohol, take medications, or want to optimize your body's detoxification capacity.

Well-Studied Options

Effective Dose200-400mg silymarin daily
Time to Effect4-8 weeks

Silymarin has antioxidant and anti-inflammatory effects on liver cells. Studies show it may help protect the liver from toxin damage and support regeneration. Most evidence is for liver damage, less for healthy livers.

Best for:General liver supportThose who drink alcoholMedication users
Effective Dose600-1800mg daily
Time to Effect2-4 weeks

NAC is a precursor to glutathione, the liver's most important antioxidant. It's actually used in hospitals for acetaminophen overdose. For general support, it helps maintain glutathione levels.

Best for:Antioxidant supportGlutathione productionDetoxification support

Specialized Options

TUDCA7/10
Effective Dose250-500mg daily
Time to Effect2-4 weeks

TUDCA is a bile acid that supports healthy bile flow and protects liver cells from stress. Used clinically in some countries for liver conditions. Good option for intensive liver support.

Best for:Bile flow supportThose on oral steroidsIntensive liver support
Effective Dose300-640mg daily
Time to Effect4-8 weeks

Artichoke extract may support bile production and has mild cholesterol-lowering effects. Traditional use for liver and digestive health. Evidence is modest but growing.

Best for:Digestive supportBile productionMild liver support

Beyond Supplements

  • Limiting alcohol is the most impactful thing you can do for liver health
  • Maintaining a healthy weight reduces fatty liver risk
  • Avoiding unnecessary medications and supplements reduces liver burden
  • Coffee consumption is associated with better liver health in studies

Note: If you have liver disease or elevated liver enzymes, work with a healthcare provider. These supplements support liver health but don't treat liver conditions.

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