**Berberine is the only supplement with effects comparable to blood sugar medication.** In trials, it lowered HbA1c by 0.5-1%, similar to metformin. Other supplements have more modest effects. None replace diet, exercise, or medication for diabetes.
Strong Evidence
Berberine activates AMPK (same pathway as metformin). Meta-analyses show it reduces fasting glucose by 15-25 mg/dL and HbA1c by 0.5-1%. Also improves lipids. Interacts with many medications.
Magnesium is required for insulin signaling. Low levels are linked to insulin resistance. Supplementation improves fasting glucose and insulin sensitivity, especially in those who are deficient (48% of Americans).
Moderate Evidence
ALA is an antioxidant that may improve insulin sensitivity and is studied for diabetic neuropathy. Evidence for blood sugar control is mixed but some trials show modest A1C reductions.
Chromium is involved in insulin signaling. Benefits are most pronounced in those who are deficient. Meta-analyses show small improvements in fasting glucose and A1C.
Blood Sugar Support Stack
For prediabetes or metabolic support (consult doctor if diabetic).
| Ingredient | Dose | When |
|---|---|---|
| Berberine | 500mg | 2-3x daily with meals |
| Magnesium Glycinate | 400mg | Evening |
| Alpha-Lipoic Acid | 300mg | Before meals |
Beyond Supplements
- •Diet is #1. Reduce refined carbs and sugar. Period.
- •Exercise (even walking) improves insulin sensitivity dramatically
- •Sleep deprivation worsens blood sugar control within days
- •Stress hormones raise blood sugar. Address chronic stress.
Note: Blood sugar management is serious. Berberine interacts with diabetes medications and can cause dangerous low blood sugar. Always work with a healthcare provider.