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47,000+ trials analyzed
59,000+ interactions
Not FDA evaluated

The Longevity Stack

Evidence-based anti-aging support

For: Adults 35+ focused on healthspan optimization

Anti-aging supplements range from well-studied to complete nonsense. This stack includes only what has real evidence for longevity markers.

TL;DR

Core: Omega-3, Vitamin D, Magnesium. Longevity-specific: CoQ10 (cellular energy), NMN/NR (NAD+ support), Creatine (muscle/brain). Lifestyle trumps all supplements.

Monthly Budget

Budget
$50
/month
Recommended
$100
/month
Premium
$200
/month

Core Stack

100-200mg dailyWith a fat-containing meal

Natural levels drop with age. Supports mitochondrial function. Critical if on statins.

Budget: Doctor's Best CoQ10 - $20/month
Premium: Thorne Q-Best - $40/month
2-3g EPA+DHAWith meals

Anti-inflammatory, cardiovascular support, brain health. Higher dose for longevity.

Budget: Sports Research Triple Strength - $20/month
Premium: Nordic Naturals ProOmega 2000 - $45/month
4000-5000 IU D3 + 200mcg K2With fatty meal

Higher dose for optimization. K2 ensures calcium goes to bones.

Budget: NOW D3+K2 - $12/month
Premium: Thorne D3/K2 - $25/month
MagnesiumESSENTIAL
400mg elementalEvening

Involved in 300+ enzyme reactions. Most are deficient.

Budget: Doctor's Best - $12/month
Premium: Pure Encapsulations - $25/month
5g dailyAny time, consistent

Muscle preservation, cognitive support, cellular energy. Not just for athletes.

Budget: Bulk powder - $8/month
Premium: Thorne Creatine - $20/month

Optional Additions

NMN or NR250-500mg NMN or 300mg NR

NAD+ precursors. Promising longevity research, but expensive and long-term human data limited.

When to add: If budget allows and comfortable with emerging research

Resveratrol250-500mg

SIRT1 activation. More hype than evidence, but some support.

When to add: If wanting to experiment, take with fats

Daily Schedule

Morning with breakfast
Vitamin D3+K2Omega-3CoQ10
Any time
Creatine (mix in water/coffee)
Evening
Magnesium

Common Mistakes

  • Skipping basics for trendy longevity supplements. D, Mg, Omega-3 first
  • Using CoQ10 ubiquinone instead of ubiquinol after 40. ubiquinol absorbs better
  • Expecting supplements to overcome poor lifestyle. sleep/exercise matter more
  • Not testing. get bloodwork to track what's actually improving

What to Expect

CoQ10: 4-8 weeks for energy. Others: ongoing support. Longevity effects measured in years, not weeks.

The Bottom Line

No pill reverses aging. These support healthy aging by addressing common deficiencies and supporting cellular function. Lifestyle > supplements.

Related Stacks

About this information: Our recommendations draw from peer-reviewed clinical trials, systematic reviews, and the same medical databases your doctor uses. These statements have not been evaluated by the FDA. Supplements are not intended to diagnose, treat, cure, or prevent any disease.

Moderate Evidence

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