Why Your Supplements Might Not Be Working (And How to Fix It)

Taking supplements but not feeling anything? Here are the most common reasons.

CS
Research Team
Check Supplement
December 24, 2025
Why Your Supplements Might Not Be Working (And How to Fix It)
Quick Answer~ It Depends

Why aren't my supplements working?

Common reasons: wrong dose, poor bioavailability form, bad timing, or not enough time.

  • Check dose vs clinical studies
  • Verify form bioavailability
  • Give 4-8 weeks
Read full explanation
You've been taking that supplement for weeks. The reviews were great, but... nothing.
01

The Dose Is Wrong

This is the #1 reason supplements fail. Many products use subtherapeutic doses. Example: Most studies on ashwagandha use 300-600mg of a standardized extract. Many products contain 50-100mg.

Quick Tips

  • Compare your dose to what studies actually used
  • Proprietary blends often hide underdosing
02

You're Taking It Wrong

Fat-soluble vitamins (A, D, E, K) need to be taken with food containing fat. Taking them on an empty stomach means you absorb almost nothing.

Iron absorbs best on an empty stomach with vitamin C.

Quick Tips

  • Take fat-soluble vitamins with meals
  • Take iron with vitamin C
03

The Form Is Garbage

Magnesium oxide is only 4% bioavailable. You'd need to take 10x more to match magnesium glycinate.

Quick Tips

  • Research bioavailability before buying
  • Sometimes paying more means absorbing more
04

You Haven't Given It Enough Time

Creatine: 2-4 weeks to saturate muscles
Fish oil: 4-8 weeks for full effects
Vitamin D: 8-12 weeks to reach optimal levels
Adaptogens: 4-8 weeks for stress resilience

Quick Tips

  • Give supplements adequate time to work
  • Track effects over weeks, not days

Key Takeaways

Before giving up on a supplement, check: dose, form, timing, and time.

Ingredients Mentioned

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