TMG (Trimethylglycine)
Solid evidence for methylation support. Not a miracle worker, but genuinely useful for the right person.
Verdict
6/10 Mixed
Evidence
Grade B / 100+ Studies
The No-BS Summary
8 things. 60 seconds. Everything you need.
WHAT IT DOES
The methyl donor that protects your heart
DOES IT WORK?
6/10 Mixed. Donates methyl groups for homocysteine conversion. Supports NMN supplementation by providing methyl groups. Also supports liver function.
HOW MUCH TO TAKE
Follow label
COST
$25-60/month depending on brand and form.
FIRST 24 HOURS
Don't expect miracles on day one. It's building in your system.
AFTER A FEW WEEKS
Most people notice something by week 2-3.
SAFETY
Safe for most people. No red flags at normal doses.
HOW IT FEELS
No obvious acute effects. Lab markers (homocysteine) improve over weeks.
QUICK ANSWERS
+ 4 more questions
DOSE-RESPONSE CURVE
How effective is creatine monohydrate at different doses? Here's what the research shows.