HIGH PRIORITY
47,000+ trials analyzed
59,000+ interactions
Not FDA evaluated

Supplements During Pregnancy

What's safe, what's essential, what to avoid

Pregnancy changes everything about supplements. Some are essential (folate), some become dangerous (vitamin A). Here's what you need to know.

TL;DR

Essential: Prenatal with folate, DHA, Vitamin D. Usually safe: Ginger (for nausea), Probiotics. Avoid: High-dose Vitamin A, most herbs, stimulants. When in doubt, ask your OB.

Why This Matters

Your baby is developing, and what you take affects them directly. Some supplements prevent birth defects (folate). Others cause them (excess vitamin A). The stakes are high, and the research is different than for non-pregnant adults.

Essential

Recommended for all pregnancies

Prevents neural tube defects

400-800mcg daily, ideally starting before conception

Covers multiple needs including iron, which increases

Start when trying to conceive if possible

Critical for baby's brain development

200-300mg DHA daily; algae-based for vegans

Supports bone development, immune function

600-4000 IU depending on levels

Usually Safe

Generally considered acceptable

For nausea; well-studied in pregnancy

Up to 1g daily for morning sickness

Generally safe, may reduce GBS colonization

Stick to well-studied strains

May help with leg cramps, constipation

Normal doses are fine; high doses used medically

Avoid

Known or potential risks

TERATOGENIC. causes birth defects above 10,000 IU

Beta-carotene is safe; preformed retinol is not

Most Herbal Supplements

Not studied in pregnancy, unknown risk

St. John's Wort, Dong Quai, Black Cohosh especially

Over 200mg daily linked to miscarriage risk

One coffee is usually fine; energy supplements are not

Stimulant Pre-Workouts

Unknown effects, often contain unsafe herbs

Just don't

What To Do

  • Start prenatal vitamin before trying to conceive
  • Discuss ALL supplements with your OB/midwife
  • Switch to pregnancy-safe alternatives where needed
  • Don't take any new supplements without asking first
  • Check that your prenatal has adequate folate, iron, DHA

Common Mistakes

  • Continuing pre-pregnancy supplement routine without review
  • Taking regular multivitamin instead of prenatal (wrong ratios)
  • Using vitamin A-containing skin products (also absorbed)
  • Assuming "natural" herbs are pregnancy-safe

The Bottom Line

Pregnancy isn't the time to experiment. Stick to proven essentials (prenatal, DHA, D), avoid unknowns, and ask your OB about everything else.

Related Safety Guides

About this information: Our recommendations draw from peer-reviewed clinical trials, systematic reviews, and the same medical databases your doctor uses. These statements have not been evaluated by the FDA. Supplements are not intended to diagnose, treat, cure, or prevent any disease.

Strong Evidence

Get Science-Backed Supplement Tips

Weekly insights from 47,000+ clinical trials

No spam. Unsubscribe anytime. We respect your inbox.

Check Your Stack for Interactions

See if your supplements have any safety concerns.

Analyze My Stack