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Thorne
SPECIMEN #THORNE-M
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B_VITAMINSThorne

Methyl-Guard Plus

The practitioner gold standard for methylation support. Every B-vitamin in its active coenzyme form. Betaine (TMG) provides methyl groups through an alternative pathway. Not a casual B-complex. This is targeted biochemistry for MTHFR and elevated homocysteine.

8.8/10
EXCELLENT

The methylation support formula that practitioners trust most. Every B-vitamin in its active coenzyme form. Betaine (TMG) provides methyl groups. Designed specifically for MTHFR and elevated homocysteine.

5 ingredientsCapsules45 servings
We'd recommend this
Evidence
10.0
Dosing
9.0
Synergy
10.0
Check My Stack
Whenmorning

B-vitamins support energy. Take with breakfast.

Foodwith food

Better tolerated with food.

SafetySome cautions

May cause over-methylation symptoms (irritability, anxiety) in sensitive individuals. Start with 1 capsule.

ResearchStrong evidence

Active B-vitamin forms, TMG, and methylation support are all individually well-researched.

What We Like

  • Every B-vitamin in active coenzyme form (P-5-P, methylcobalamin, methylfolate, R-5-P).
  • Betaine (TMG) provides an alternative methylation pathway.
  • Specifically designed for MTHFR variants and elevated homocysteine.
  • Thorne's practitioner-grade quality.

Watch Out For

  • Not a general B-complex (it's targeted for methylation).
  • Premium pricing.
  • May over-methylate some individuals.

Ingredient Breakdown

1 clinical1 underdosed
Clinical Adequate Underdosed Overdosed|Bar = % of clinical dose
IngredientDoseStatusvs. Clinical
Folate10.0

5-MTHF L-Methylfolate

1700 mcg DFEOVERDOSED
213%
1700 mcg DFE

of 800mcg

OVERDOSED
213%
Vitamin B1210.0

Methylcobalamin

2000 mcgOVERDOSED
200%
2000 mcg

of 1000mcg

OVERDOSED
200%
Vitamin B6

Pyridoxal-5-Phosphate

45 mgOVERDOSED
450%
45 mg

of 10mg

OVERDOSED
450%
Vitamin B210.0

Riboflavin-5-Phosphate

25 mgCLINICAL
100%
25 mg

of 25mg

CLINICAL
100%
Betaine8.0

Trimethylglycine

750 mgUNDERDOSED
30%
750 mg

of 2500mg

UNDERDOSED
30%
In our database (click to learn more) Not yet reviewed

Our Analysis

Best For

People with MTHFR variants (confirmed by genetic testing).Those with elevated homocysteine.Patients directed by practitioners.

Skip This If

People without methylation issues (regular B-complex is sufficient).Those sensitive to methylation support (start slow).

Time to Feel

2-4 weeks. Homocysteine changes measurable at 8-12 weeks.

Value

GOOD

How to take: No cycling needed if methylation support is indicated.

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