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Nature Made Vitamin E 400 IU
SPECIMEN #NATURE-M
Verified
VitaminsNature Made

Vitamin E 400 IU

High-dose synthetic vitamin E is one of the most debunked supplement trends. SELECT trial: no cancer prevention. Meta-analyses: may increase mortality. Synthetic form depletes gamma-tocopherol (the important one). Eat nuts instead. Seriously.

4.0/10
POOR

Synthetic dl-alpha tocopherol at 400 IU. SELECT trial showed no prostate cancer prevention. Meta-analyses suggest high-dose synthetic E may increase all-cause mortality. Natural mixed tocopherols are the better choice.

1 ingredientSoftgels100 servings
We'd look at alternatives
Evidence
3.0
Dosing
4.0
SynergyN/A (single ingredient)
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WhenN/A

Reconsider taking it.

FoodN/A

N/A

SafetySome cautions

High-dose synthetic vitamin E may increase all-cause mortality per meta-analyses. Depletes gamma-tocopherol.

ResearchStrong evidence

SELECT trial, meta-analyses document risks of high-dose synthetic E.

What We Like

  • 100 softgels.
  • USP Verified.

Watch Out For

  • Synthetic dl-alpha has 50% bioactivity of natural d-alpha.
  • SELECT trial: no cancer prevention benefit.
  • Meta-analyses: high-dose synthetic E may increase mortality.
  • Displaces gamma-tocopherol (which may be more important).
  • The entire high-dose isolated vitamin E approach is outdated.

What We Analyzed

Vitamin E 400 IU Supplement Facts

Verified Supplement Facts

Every dose checked against clinical research

We analyzed the actual supplement facts panel for this product. Every ingredient dose below was cross-referenced with published clinical trials to determine if it matches what studies actually use.

1 ingredients analyzed1 at clinical doses

Source: Official product page

Ingredient Breakdown

1 clinical
Clinical Adequate Underdosed Overdosed|Bar = % of clinical dose
IngredientDoseStatusvs. Clinical
Vitamin E10.0

dl-Alpha Tocopherol

180 mgCLINICAL
134%
180 mg

of 200IU

CLINICAL
134%
In our database (click to learn more) Not yet reviewed

Our Analysis

Best For

Almost no one based on current evidence.

Skip This If

Everyone unless specifically prescribed.

Time to Feel

No benefit expected.

Value

POOR

How to take: Don't start.

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