goal
47,000+ trials analyzed
59,000+ interactions
Not FDA evaluated

Sleep Supplements: Complete Guide

Evidence-based supplements for falling asleep faster, staying asleep, and waking refreshed.

Quick Summary

Evidence-based supplements for falling asleep faster, staying asleep, and waking refreshed. Varies by supplement. See individual recommendations.

4
Proven Benefits
N/A
Forms Available
5
Use Cases

What is Sleep Supplements?

Sleep supplements include a range of nutrients, herbs, and compounds that support natural sleep processes. Unlike sleep medications, they work with your body's systems rather than forcing sedation. The best approach combines multiple synergistic ingredients.

Who Should Consider Sleep Supplements?

  • Those with difficulty falling asleep (sleep onset insomnia)
  • People who wake during the night (maintenance insomnia)
  • Anyone with anxiety-related sleep issues
  • Shift workers and jet-lagged travelers
  • Those wanting to avoid habit-forming sleep aids

How It Works

Different sleep supplements target different mechanisms: GABA enhancement (magnesium, L-theanine), melatonin production (tryptophan), body temperature regulation (glycine), and cortisol reduction (ashwagandha). The most effective stacks combine multiple pathways.

Benefits & Evidence

Sleep Supplements has 4 strongly-evidenced benefits and 0 moderately-evidenced benefits.

Faster sleep onset

strong evidence

Magnesium + L-theanine reduces time to fall asleep by 37%

Better sleep quality

strong evidence

Multiple supplements improve deep sleep percentage

Non-habit forming

strong evidence

Unlike prescription sleep aids, no dependence develops

Anxiety reduction

strong evidence

Addresses root cause of anxiety-related insomnia

Dosing & Timing

Recommended Doses

Standard DoseVaries by supplement. See individual recommendations
Clinical DoseStack approach typically most effective
Maximum DailyDon't exceed individual supplement limits

Timing

When to Take30-60 minutes before bed
With Food?Not required
DurationCan be used nightly; rotate if tolerance develops

Side Effects & Interactions

Possible Side Effects

  • Morning grogginess (with melatonin). Common if dose too high
  • Vivid dreams. Occasional

Interactions to Know

  • May enhance effects of sedative medications
  • Melatonin may interact with blood thinners
  • Ashwagandha may affect thyroid medications

Frequently Asked Questions

Magnesium glycinate is our #1 recommendation. Addresses deficiency in 70% of adults and improves both onset and quality. Add L-theanine for racing mind.

Related Topics

About this information: Our analysis of Sleep Supplements is based on peer-reviewed research from PubMed, ClinicalTrials.gov, and NIH databases. These statements have not been evaluated by the FDA. Supplements are not intended to diagnose, treat, cure, or prevent any disease.

Moderate Evidence

Get Science-Backed Supplement Tips

Weekly insights from 47,000+ clinical trials

No spam. Unsubscribe anytime. We respect your inbox.

Sources