Folinic Acid (Active Folate)
Solid evidence for methylation support. Not a miracle worker, but genuinely useful for the right person.
Verdict
6/10 Mixed
Evidence
Grade B / 100+ Studies
The No-BS Summary
8 things. 60 seconds. Everything you need.
WHAT IT DOES
Bypasses MTHFR mutations differently than methylfolate.
DOES IT WORK?
6/10 Mixed. Reduced folate that can enter the folate cycle without MTHFR. Alternative to methylfolate for some people who dont tolerate it. Used in medical settings for methotrexate rescue.
HOW MUCH TO TAKE
Follow label
COST
$25-60/month depending on brand and form.
FIRST 24 HOURS
Don't expect miracles on day one. It's building in your system.
AFTER A FEW WEEKS
Most people notice something by week 2-3.
SAFETY
Safe for most people. No red flags at normal doses.
HOW IT FEELS
Folate benefits for those who dont tolerate methylfolate.
QUICK ANSWERS
+ 4 more questions
DOSE-RESPONSE CURVE
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