SAM-e (S-Adenosyl Methionine)
One of the few supplements that actually delivers. Proven to support depression with real clinical backing.
Verdict
8/10 Solid
Evidence
Grade B / 100+ Studies
The No-BS Summary
8 things. 60 seconds. Everything you need.
WHAT IT DOES
Methyl donor master. Depression fighter with joint benefits.
DOES IT WORK?
8/10 Solid. Good pick. Universal methyl donor. Strong evidence for depression comparable to SSRIs. Also helps joints and liver. Expensive but effective.
HOW MUCH TO TAKE
400-1600mg daily
COST
Premium. $50-80/month. Make sure the evidence backs the spend.
FIRST 24 HOURS
Don't expect miracles on day one. It's building in your system.
AFTER A FEW WEEKS
Give it 4-8 weeks for full effects. Patience pays.
SAFETY
Few things to check: bipolar_caution, serotonin_caution. Worth mentioning to your doc.
HOW IT FEELS
Lifted mood, better joint mobility over time.
QUICK ANSWERS
+ 4 more questions
DOSE-RESPONSE CURVE
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