SAMe (S-Adenosyl Methionine)
Solid evidence for depression. Not a miracle worker, but genuinely useful for the right person.
Verdict
7/10 Solid
Evidence
Grade B / 100+ Studies
The No-BS Summary
8 things. 60 seconds. Everything you need.
WHAT IT DOES
Natural antidepressant and joint support. Expensive but effective.
DOES IT WORK?
7/10 Solid. Good pick. Methyl donor involved in 200+ reactions. Strong evidence for depression (comparable to some antidepressants), osteoarthritis, and liver health. Expensive and stability issues. Enteric coating essential.
HOW MUCH TO TAKE
Follow label
COST
$25-60/month depending on brand and form.
FIRST 24 HOURS
Don't expect miracles on day one. It's building in your system.
AFTER A FEW WEEKS
Most people notice something by week 2-3.
SAFETY
Safe for most people. No red flags at normal doses.
HOW IT FEELS
Mood lift within 2 weeks. Joint benefits over months.
QUICK ANSWERS
+ 4 more questions
DOSE-RESPONSE CURVE
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