May support mitochondrial health and energy production, but evidence is limited at typical supplement doses.
Effective Dose
10-20 mg
Onset
2-4 weeks
Cost
Mid-range
Cycle
Not typically cycled, but long-term effects are not fully known.
Why not higher?
7 things you need to know
What it does
May support mitochondrial health and energy production, but evidence is limited at typical supplement doses.
Worth it?
3/10. PQQ shows promise in animal and in-vitro studies for mitochondrial biogenesis and antioxidant effects. However, human evidence at realistic supplement doses is weak and inconsistent. Overhyped based on preliminary research.
How much to take
10-20 mg
Price
Moderate ($15-30/month)
How fast it works
Takes 2 to 4 weeks to notice
Safety
Check if: may interact with blood thinners., insufficient data on long-term safety.
What people say
Some users report increased energy levels and improved cognitive function, but these effects are not consistently observed and could be placebo.
PQQ was originally discovered in bacteria and is found in various foods, including natto (fermented soybeans).
"Some users report increased energy levels and improved cognitive function, but these effects are not consistently observed and could be placebo."
Research backing for this ingredient
Some evidence, more research needed
6+
Not yet
Mixed opinions in scientific community
Improves cognitive function and memory
Single RCT (n=71) and one open-label study (n=41)
Reduces inflammatory markers (CRP, IL-6)
Small crossover trial (n=10)
Improves sleep quality and fatigue
Single RCT (n=17)
"The scientific community acknowledges PQQ's potential based on preclinical studies, but there is a lack of robust human trials to confirm its benefits at typical supplement doses. More research is needed."
PQQ is claimed to support energy production within cells by promoting mitochondrial health and acting as an antioxidant. However, human studies are limited, and the benefits are not well-established at typical supplement doses.
Products below minimum dose are likely ineffective
When
Any time
How
10-20 mg
Food
Can be taken with or without food.
Noticeable effects, if any, may take several weeks of consistent supplementation.
Not typically cycled, but long-term effects are not fully known.
Check for specific interactions.
PQQ is categorized as a antioxidant.
Scientific consensus score: 4/10.
Evidence quality: WEAK.
Add PQQ to your stack analyzer or compare it with other ingredients.
Not medical advice. Always consult a healthcare provider.