Low-Dose Naltrexone (LDN)
The addiction drug repurposed for inflammation. Evidence is mixed, so set expectations accordingly.
Verdict
5/10 Mixed
Evidence
Grade B / 100+ Studies
The No-BS Summary
8 things. 60 seconds. Everything you need.
WHAT IT DOES
The addiction drug repurposed for inflammation
DOES IT WORK?
5/10 Mixed. At low doses (1-5mg), modulates immune function rather than blocking opioids. Growing evidence for autoimmune conditions and chronic pain. Requires prescription.
HOW MUCH TO TAKE
Follow label
COST
$25-60/month depending on brand and form.
FIRST 24 HOURS
Don't expect miracles on day one. It's building in your system.
AFTER A FEW WEEKS
Most people notice something by week 2-3.
SAFETY
Safe for most people. No red flags at normal doses.
HOW IT FEELS
Vivid dreams initially. Pain and fatigue improvements over weeks in responders.
QUICK ANSWERS
+ 4 more questions
DOSE-RESPONSE CURVE
How effective is creatine monohydrate at different doses? Here's what the research shows.