Methylfolate (5-MTHF)
One of the few supplements that actually delivers. Proven to support folate with real clinical backing.
Verdict
8/10 Solid
Evidence
Grade B / 100+ Studies
The No-BS Summary
8 things. 60 seconds. Everything you need.
WHAT IT DOES
Active folate. Bypasses MTHFR issues.
DOES IT WORK?
8/10 Solid. Good pick. The active form of folate. Essential for MTHFR gene variants. Better absorbed and utilized than folic acid.
HOW MUCH TO TAKE
See product label
COST
Mid-range. $35-50/month. Standard for most people.
FIRST 24 HOURS
Don't expect miracles on day one. It's building in your system.
AFTER A FEW WEEKS
Give it 4-8 weeks for full effects. Patience pays.
SAFETY
Safe for most people. No red flags at normal doses.
HOW IT FEELS
Better energy and mood for some.
QUICK ANSWERS
+ 4 more questions
DOSE-RESPONSE CURVE
How effective is creatine monohydrate at different doses? Here's what the research shows.