Timing can affect absorption and side effects. But don't overcomplicate it. The best time is whenever you'll actually remember to take them consistently.
Morning Champions
B Vitamins / B Complex - Can be energizing - May interfere with sleep if taken late
Vitamin D - Some find it mildly energizing - Take with breakfast containing fat
Iron (if taking) - Best on empty stomach for absorption - Take with vitamin C - Keep away from coffee/tea
CoQ10 - May boost energy - Take with breakfast
Evening or Bedtime
Magnesium (especially glycinate) - Promotes relaxation - Helps with sleep - Take 1-2 hours before bed
Probiotics - Some evidence for bedtime (lower stomach acid) - But consistency matters more than timing
Omega-3s - Can take any time with food - Evening fine if that's more consistent
Whenever Works
Creatine - Timing doesn't matter. Just daily.
Collagen - Any time. Consistency is key.
Multivitamins - With any meal. Food reduces nausea.
Protein powder - Around workouts or whenever you need protein.
Avoid Together
Iron + Calcium - Compete for absorption. Take 2+ hours apart.
Iron + Coffee/Tea - Reduces absorption 80%. Wait an hour.
Zinc + Copper - High zinc depletes copper long-term.
Thyroid meds + Everything - Take thyroid medication alone, 30-60 minutes before other supplements.
The Bottom Line
The "perfect" timing matters less than actually taking your supplements. Pick a routine that works for your schedule and stick with it.