EVIDENCE-BASED
47,000+ trials analyzed
59,000+ interactions
Not FDA evaluated

What Actually Works for Weight Loss?

The weight loss supplement industry is worth $33 billion and almost none of it works. Here's the honest truth about what supplements can and can't do for fat loss.

TL;DR

Best evidence: Caffeine (modest), Fiber (satiety), Protein (preserves muscle). Moderate evidence: Green tea extract (small effect). Doesn't work: Fat burners, garcinia cambogia, raspberry ketones, CLA, and 99% of what's marketed.

B

Modest Evidence (Helps Around Edges)

Caffeine
100-400mg daily40 studies

Slightly increases metabolic rate and fat oxidation

30-60 minutes

Note: Effect is small. Maybe 100 extra calories burned. Tolerance develops.

Fiber Supplements
10-30g daily25 studies

Increases satiety, reduces calorie absorption slightly

Immediate satiety

Note: Food fiber is better. Supplements help if diet is low.

Protein Supplements
1.6-2.2g/kg body weight (total)50 studies

Preserves muscle during calorie restriction

Ongoing

Note: Doesn't burn fat directly. Helps body composition.

C

Weak Evidence (Minimal Effect)

Green Tea Extract (EGCG)
250-500mg EGCG daily15 studies

May slightly increase fat oxidation

8-12 weeks

Note: Effect is maybe 1-2 lbs over months. Not magic.

Conjugated Linoleic Acid (CLA)
3-4g daily18 studies

Tiny effect on body composition in some studies

12+ weeks

Note: Results are inconsistent and small.

F

Doesn't Work (Save Your Money)

Garcinia Cambogia
Any

Meta-analyses show no meaningful weight loss

N/A

Note: Dr. Oz made it famous. Research says it's useless.

Raspberry Ketones
Any

Zero human evidence of any kind

N/A

Note: Only works in petri dishes and mice. Not humans.

Fat Burners / Thermogenics
Various

Usually just caffeine with random herbs

N/A

Note: The caffeine might help slightly. The rest doesn't.

Carb Blockers
Various

Block minimal carbs, cause GI distress

N/A

Note: You'll get gas, not results.

Real Talk

Here's what the $33 billion weight loss supplement industry doesn't want you to know: almost nothing works. Weight loss happens from a calorie deficit. Full stop. Supplements can't create a deficit. They can, at most, make it slightly easier to maintain one. If something promises easy weight loss, it's lying to you.

What Else Actually Helps

  • Calorie deficit. the only thing that actually causes fat loss
  • Protein. 1.6g/kg minimum to preserve muscle
  • Strength training. maintains metabolism and muscle
  • Sleep. poor sleep increases hunger hormones
  • Walking. underrated for calorie burn and sustainability

The Bottom Line

No pill will make you lose weight. Caffeine and fiber might help you eat less. Protein preserves muscle. Everything else is expensive placebo. Focus on diet and exercise.

Related Guides

About this information: Our recommendations draw from peer-reviewed clinical trials, systematic reviews, and the same medical databases your doctor uses. These statements have not been evaluated by the FDA. Supplements are not intended to diagnose, treat, cure, or prevent any disease.

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