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LONGEVITYDoNotAge

Fisetin 500mg

The most potent natural senolytic (zombie cell killer) in animal studies. Mayo Clinic is running human trials. But zero published human results. We don't know the dose, frequency, or safety in humans. Exciting science. Premature supplementation.

5.5/10
DECENT

The most promising senolytic compound in preclinical research. Clears senescent (zombie) cells in mice, extending lifespan. But zero completed human longevity trials. Pure speculation at this point.

1 ingredientCapsules30 servings
We'd look at alternatives
Evidence
6.0
Dosing
5.0
SynergyN/A (single ingredient)
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Whenintermittent

Some longevity researchers suggest 2-day 'senolytic bursts' monthly rather than daily.

Foodwith food

Fat-soluble. May improve poor bioavailability.

SafetySome cautions

No human safety data for long-term supplementation. Theoretical cancer concern (clears some cells that may be protective).

ResearchLimited evidence

Strong mouse data. Mayo Clinic human trials ongoing. No published human longevity results.

What We Like

  • Most potent natural senolytic identified in research.
  • 500mg matches doses discussed in longevity community.
  • Mayo Clinic is running human trials.
  • Mechanism of action (senescent cell clearance) is well-understood.

Watch Out For

  • ZERO completed human trials for longevity.
  • Optimal dosing for humans is unknown.
  • Bioavailability of fisetin is poor.
  • $40+/month for an unproven compound.

Ingredient Breakdown

1 clinical
Clinical Adequate Underdosed Overdosed|Bar = % of clinical dose
IngredientDoseStatusvs. Clinical
Fisetin8.0

from Smoketree (Cotinus coggygria)

500 mgCLINICAL
100%
500 mg

of 500mg

CLINICAL
100%
In our database (click to learn more) Not yet reviewed

Our Analysis

Best For

Longevity researchers and self-experimenters.People comfortable with unproven compounds.

Skip This If

Risk-averse individuals.Anyone wanting evidence-based supplementation.Cancer patients (theoretical concern).

Time to Feel

No subjective effects expected. Longevity effects are unmeasurable.

Value

POOR

How to take: If using: intermittent dosing (2 days/month) not daily, per animal protocol.

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