Zinc: Complete Guide
Essential mineral for immunity, testosterone, and wound healing. 15% of adults are deficient.
Quick Summary
Essential mineral for immunity, testosterone, and wound healing. 15% of adults are deficient. 15-30mg elemental zinc daily. Best form: Picolinate.
What is Zinc?
Zinc is an essential trace mineral involved in 300+ enzymes and 1,000+ transcription factors. It's critical for immune function, protein synthesis, wound healing, and DNA synthesis. Your body can't store it, so you need consistent intake.
Who Should Consider Zinc?
- Vegetarians and vegans (plant zinc is less bioavailable)
- Athletes (lost through sweat)
- Elderly adults (absorption decreases with age)
- Men concerned about testosterone
- Anyone with frequent colds or slow wound healing
- People with digestive issues (reduces absorption)
How It Works
Zinc supports immune cell function (T-cells and natural killer cells), acts as a cofactor for enzymes that repair tissue, and regulates testosterone production in men. It also has antioxidant properties and supports the gut lining.
Forms Comparison
Different forms of Zinc have varying absorption rates and best uses. Here's how they compare:
| Form | Bioavailability | Best For |
|---|---|---|
| Picolinate | 20% | Well absorbed. Good all-around choice. |
| Glycinate/Bisglycinate | 25% | Best absorbed. Gentle on stomach. Premium. |
| Citrate | 15% | Decent absorption. Budget friendly. |
| Gluconate | 10% | Common in lozenges. OK for colds, not great otherwise. |
| Oxide | 5% | Avoid. Poorly absorbed. Cheap but worthless. |
Our recommendation: Picolinate for most people due to superior absorption and tolerability.
Benefits & Evidence
Zinc has 2 strongly-evidenced benefits and 2 moderately-evidenced benefits.
Immune function
strong evidenceReduces cold duration by 33% when taken within 24 hours
Testosterone support
moderate evidenceRestores T levels in deficient men. Won't exceed natural ceiling.
Wound healing
strong evidenceEssential cofactor for tissue repair enzymes
Acne reduction
moderate evidence30mg daily showed comparable effects to antibiotics in trials
Dosing & Timing
Recommended Doses
Timing
Side Effects & Interactions
Possible Side Effects
- Nausea on empty stomach. Common
- Copper depletion (high doses). With chronic high doses
- Metallic taste. Occasional
Interactions to Know
- Competes with copper (take copper if using 30mg+ zinc long-term)
- Reduces absorption of fluoroquinolone antibiotics
- Iron and calcium reduce zinc absorption (take separately)
Frequently Asked Questions
Blood tests exist but aren't super reliable. Symptoms: slow wound healing, frequent colds, low testosterone, poor taste/smell. Vegetarians and athletes should assume mild deficiency.
Related Topics
About this information: Our analysis of Zinc is based on peer-reviewed research from PubMed, ClinicalTrials.gov, and NIH databases. These statements have not been evaluated by the FDA. Supplements are not intended to diagnose, treat, cure, or prevent any disease.
Get Science-Backed Supplement Tips
Weekly insights from 47,000+ clinical trials
No spam. Unsubscribe anytime. We respect your inbox.
Add Zinc to Your Stack
Track it alongside your other supplements for interaction checking.