Vitamin D: Complete Guide
The "sunshine vitamin" that 42% of Americans are deficient in. Critical for immunity, bones, and mood.
Quick Summary
The "sunshine vitamin" that 42% of Americans are deficient in. Critical for immunity, bones, and mood. 1,000-2,000 IU daily for maintenance. Best form: D3 (Cholecalciferol).
What is Vitamin D?
Vitamin D is a fat-soluble hormone precursor that your skin produces from sunlight. It regulates calcium absorption, immune function, and over 200 genes. Unlike most vitamins, it acts more like a hormone, affecting nearly every cell in your body.
Who Should Consider Vitamin D?
- Anyone living above 35°N latitude (most of US/Europe)
- People with darker skin (need more sun exposure)
- Those who work indoors or use sunscreen
- Adults over 65 (skin produces 75% less vitamin D)
- People with depression, especially seasonal
- Those with autoimmune conditions
How It Works
When you take vitamin D3, your liver converts it to 25(OH)D (what blood tests measure). Your kidneys then activate it to 1,25(OH)D, which binds to vitamin D receptors throughout your body, regulating gene expression for immunity, mood, and bone health.
Forms Comparison
Different forms of Vitamin D have varying absorption rates and best uses. Here's how they compare:
| Form | Bioavailability | Best For |
|---|---|---|
| D3 (Cholecalciferol) | 90% | Everyone. mimics what skin produces, more effective than D2 |
| D2 (Ergocalciferol) | 50% | Vegans only (plant-derived). less effective but vegan-friendly |
Our recommendation: D3 (Cholecalciferol) for most people due to superior absorption and tolerability.
Benefits & Evidence
Vitamin D has 2 strongly-evidenced benefits and 2 moderately-evidenced benefits.
Immune function
strong evidence40% reduction in respiratory infections with adequate levels
Bone health
strong evidenceEssential for calcium absorption; prevents osteoporosis
Mood & depression
moderate evidenceDeficiency linked to 14% higher depression risk
Muscle function
moderate evidenceReduces fall risk by 19% in elderly
Autoimmune support
emerging evidenceMay reduce risk of MS, Type 1 diabetes, RA
Dosing & Timing
Recommended Doses
Timing
Side Effects & Interactions
Possible Side Effects
- Hypercalcemia (at very high doses). Rare
- Nausea. Uncommon
Interactions to Know
- Requires adequate magnesium for activation
- Pair with K2 for bone benefits (directs calcium to bones)
- May interact with some heart medications
- Synergistic with omega-3 for inflammation
Frequently Asked Questions
D3 is 87% more effective at raising blood levels and has longer shelf life. Use D3 unless you're strictly vegan.
Related Topics
About this information: Our analysis of Vitamin D is based on peer-reviewed research from PubMed, ClinicalTrials.gov, and NIH databases. These statements have not been evaluated by the FDA. Supplements are not intended to diagnose, treat, cure, or prevent any disease.
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