May support mood and joint health.
Effective Dose
200-400mg
Onset
2-4 weeks
Cost
Premium
Cycle
SAMe can be taken daily, but it's advisable to consult with a healthcare provider for long-term use.
7 things you need to know
What it does
May support mood and joint health.
Worth it?
6/10. SAMe shows promise for mood and joint support, but its effectiveness can vary. It may be helpful for some, but it's not a guaranteed solution and may not work for everyone.
How much to take
200-400mg
Price
Pricey ($30+/month)
How fast it works
Takes 2 to 4 weeks to notice
Safety
Check if: bipolar disorder, anxiety disorders
What people say
Some users report improved mood and reduced joint discomfort, while others may not experience noticeable effects.
SAMe is naturally produced in the body from methionine and ATP. It was first discovered in 1953.
"Some users report improved mood and reduced joint discomfort, while others may not experience noticeable effects."
Research backing for this ingredient
Some evidence, more research needed
Limited
Not yet
Generally accepted with some debate
"While some studies suggest potential benefits, more research is needed to confirm SAMe's effectiveness, especially at typical supplement doses. The evidence is considered mixed."
SAMe is involved in many biochemical reactions in the body, particularly in the liver and brain. Supplementing with SAMe may help support these functions.
Products below minimum dose are likely ineffective
When
Any time
How
200-400mg
Food
Take with or without food, but consistency is key.
Effects may take several weeks to become noticeable.
SAMe can be taken daily, but it's advisable to consult with a healthcare provider for long-term use.
Check for specific interactions.
SAMe (S-Adenosyl Methionine) is categorized as a amino acid.
Scientific consensus score: 6/10.
Evidence quality: MODERATE.
Add SAMe (S-Adenosyl Methionine) to your stack analyzer or compare it with other ingredients.
Not medical advice. Always consult a healthcare provider.