May subtly sharpen focus and reduce stress under pressure.
Effective Dose
100-300mg
Onset
2-4 weeks
Cost
Mid-range
Cycle
No cycling is typically required, but assess effectiveness after 2-3 months.
Why not higher?
7 things you need to know
What it does
May subtly sharpen focus and reduce stress under pressure.
Worth it?
5.5/10. Phosphatidylserine (PS) shows some promise for cognitive function and stress reduction, particularly under stressful conditions. However, the effects are often subtle and may not be noticeable for everyone. Evidence is mixed, and results are not dramatic at typical supplement doses.
How much to take
100-300mg
Price
Moderate ($15-30/month)
How fast it works
Takes 2 to 4 weeks to notice
Safety
Check if: blood thinners, pregnancy
What people say
Users may experience a subtle calming effect, improved focus during stressful situations, and potentially better sleep quality. Effects are generally subtle and not always noticeable.
Originally derived from bovine brain, now commonly extracted from soy or sunflower lecithin.
"Users may experience a subtle calming effect, improved focus during stressful situations, and potentially better sleep quality. Effects are generally subtle and not always noticeable."
Research backing for this ingredient
Several studies show positive results
45+
Yes
Generally accepted with some debate
Improves memory and cognitive function in elderly individuals
Systematic reviews of multiple RCTs
Blunts cortisol response to acute physical stress
Several RCTs (n=9 to n=75)
Reduces ADHD symptoms in children
Meta-analysis of 6 RCTs
"While some studies show benefits, particularly for cognitive function and stress response, other studies show minimal to no effect. The inconsistency in results and the subtle nature of the effects contribute to the moderate consensus."
Phosphatidylserine is a phospholipid that supports brain cell function and may help manage stress. Supplementation aims to boost these effects, but results vary.
Products below minimum dose are likely ineffective
When
Any time
How
100-300mg
Food
Can be taken with or without food.
Noticeable effects, if any, usually appear after 2-4 weeks of consistent use.
No cycling is typically required, but assess effectiveness after 2-3 months.
Check for specific interactions.
Phosphatidylserine is categorized as a fatty acid.
Scientific consensus score: 6/10.
Evidence quality: MODERATE.
Add Phosphatidylserine to your stack analyzer or compare it with other ingredients.
Not medical advice. Always consult a healthcare provider.